Fieller's Confidence Intervals
Incremental Cost-Effectiveness
Calculator and Plotter

Health Decision Strategies, LLC.

Data Entry Page
--  Beta version, for demonstration only -

Data Entry for: Incremental
Cost Effectiveness Ratio

 For this first section of boxes, change the values in the four center white boxes and click "Calculate" to display the Incremental Cost Effectiveness Ratio (ICER)




Incremental Analysis

Costs (Inputs)

Effectiveness (Outcomes)



Cost Effectiveness Ratio Slope=(Cost/Effect)




Data Entry for: Fieller's
95% Confidence Intervals

In order to calculate Fieller's Confidence Intervals (CI) for a Cost-Effectiveness Ratio, values must be entered for the eight boxes directly below. With the dataset of cost and effects for each individual patient, these values can be generated from a spreadsheet program like MS Excel.



Number of Cases
Cost Standard Deviation
Effect Standard Deviation
Cost-Effect Correlation

97.5% Slope

2.5% Slope
Fieller's CI

Sample Chart from Results Page

1. Kerelakes DJ, Obenchain RL et al. Abciximab provides cost-effective survival advantage in high-volume interventional practice. Am. Heart J. 140:603-10; 2000.
2. Obenchain RL. Resampling and multiplicity in cost-effectiveness inference. J. Biopharmaecutical Statistics. 9(4), 563-582, 1999.
3. Obenchain RL et al. Bootstrap analyses of cost effectiveness in antidepressant pharmacotherapy. PharmacoEconomics. 11(5):464-472, 1997.
4. Briggs AH, O’Brien BJ, and Blackhouse G. Thinking Outside the Box: Recent Advances in the Analysis and Presentation of Uncertainty in Cost-Effectiveness Studies. Annual Rev. Public Health. 23:377–401, 2002.

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